FMOC-PAL AM RESIN

Fmoc-PAL AM Resin

Fmoc-PAL AM Resin

Blog Article

Resin Rundown: Meet Fmoc-PAL AM Resin – Your Go-To for Peptide Amides


In peptide chemistry, the C-terminus can make or break a molecule's bioactivity, solubility, and stability. If you're aiming for C-terminal amide peptides—a hallmark of many natural and therapeutic peptides—then Fmoc-PAL AM Resin is your best friend in the lab.







 What is Fmoc-PAL AM Resin?


Fmoc-PAL AM Resin is a polystyrene-based solid support functionalized with a 4-(4-aminomethyl-3,5-dimethoxyphenoxy)butyric acid (PAL) linker, pre-loaded with an Fmoc-protected amine. It’s specifically designed for Fmoc/tBu solid-phase peptide synthesis (SPPS) and delivers peptides with a C-terminal amide upon TFA cleavage.





  • Fmoc: Fluorenylmethyloxycarbonyl protecting group for the N-terminus




  • PAL Linker: Acid-labile linker for mild cleavage conditions




  • AM = Amide: Indicates the peptide will have a C-terminal –NH₂ after cleavage







 Key Features


C-terminal Amide Formation – Perfect for peptides mimicking native sequences


Mild Cleavage – Linker is TFA-sensitive, preserving side chains with minimal degradation


High Purity – Produces clean, amide-terminated peptides


Compatible with Automation – Works well in automated SPPS systems






 Why Choose Fmoc-PAL AM Resin?


Many bioactive peptides (hormones, neuropeptides, etc.) exist naturally as amides at the C-terminus, which improves their stability, receptor binding, and in vivo half-life. Fmoc-PAL AM Resin lets you easily recreate that native amide structure during synthesis.


It’s especially favored for:







 Specifications at a Glance:




  • Resin Type: Cross-linked polystyrene (typically 1% DVB)




  • Linker: PAL (acid-labile, amide-yielding)




  • Particle Size: ~100–200 mesh (75–150 µm)




  • Loading: ~0.2–0.4 mmol/g




  • Cleavage: TFA (trifluoroacetic acid) yields peptide amide







 Storage & Handling Tips




  • Keep dry at 2–8 °C, away from moisture




  • Swell in DMF or DCM before synthesis




  • Minimize exposure to air and light for long-term storage







Final Thoughts


If your goal is to produce peptides with C-terminal amides that mirror their natural or therapeutic counterparts, Fmoc-PAL AM Resin is the gold standard. Clean cleavages, high purity, and predictable performance—what more could you ask for in a resin?

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