NovaSyn TGR R resin
NovaSyn TGR R resin
Blog Article
NovaSyn® TGR (TentaGel R) resin is a high-performance PEG-grafted polystyrene resin functionalized with a Rink amide linker, ideal for Fmoc/tBu SPPS. It is commonly used for the synthesis of C-terminal peptide amides, a feature found in many bioactive peptides and therapeutic candidates.
Key Features:
Resin Type: TentaGel (PEG-grafted polystyrene)
Linker: Rink Amide (acid-labile, generates amide C-terminus)
Functional Group: Primary amine (via Rink amide)
Cleavage Condition: TFA (Trifluoroacetic acid), yields C-terminal amides
Typical Loading: ~0.2–0.3 mmol/g (optimized for purity and yield)
Particle Size: Generally 90–140 µm (depending on source)
Swelling: Excellent swelling in polar solvents like DMF, DCM, NMP
Advantages:
Produces C-terminal amide peptides, mimicking natural peptides and increasing biological stability.
Low substitution improves purity by minimizing aggregation during synthesis.
PEGylation offers enhanced swelling and diffusion, increasing synthesis efficiency—especially for longer peptides.
Compatible with automated and manual SPPS workflows.
Ideal For:
Therapeutic peptide synthesis (many drugs end with amides)
Long peptide chains or difficult sequences
Applications where hydrophilicity and high solvation are beneficial
Storage:
Store dry, at 2–8 °C, away from light and moisture.
Keep sealed under inert atmosphere when possible.
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